سیده زهرا بختی – گروه بیولوژی سلولی و مولکولی، بخش زیست شناسی، دانشکده علوم، دانشگاه محقق اردبیلی،
سعید لطفی نوید – گروه بیولوژی سلولی و مولکولی، بخش زیست شناسی، دانشکده علوم، دانشگاه محقق اردبیلی،
صابر زهری – گروه بیولوژی سلولی و مولکولی، بخش زیست شناسی، دانشکده علوم، دانشگاه محقق اردبیلی
Helicobacter pylori is a human gastric pathogen that colonizes the stomach and duodenum. This bacterium, which infects
more than half of all humans, is the causative agent of gastric cancer, the second leading cause of cancer death worldwide. Gastric cancer incidence rate correlates with H. pylori prevalence in some areas of the world, but this relationship is not consistently observed. There are regions where infection is nearly universal, but rates of gastric cancer are low. For example, in Africa nearly 100% of the population is infected, but the rate of gastric cancer is quite low. Genetic studies have established that the bacterium is highly diverse and that this diversity is geographically and ethnically structured. For example, H. pylori strains from East Asia are distinct from those observed in Europe. Global epidemiology studies have shown that the phylogeographic origin of H. pylori associates with the different histopathological scores and the prevalence of gastric cancer, whereas local epidemiology studies have shown that the virulence factors are better predictive factor of gastric cancer than the phylogeographic origin. Further studies are required to confirm the relationship between the ancestral origin of H. pylori and clinical outcome.
Keywords: Helicobacter pylori, Gastric cancer, Ancestral origin, Virulence factors